An expanded pharmacogenomics warfarin dosing table with utility in generalised dosing guidance

An expanded pharmacogenomics warfarin dosing table with utility in generalised dosing guidance.

Pharmacogenomics (PGx) guided warfarin dosing, using a comprehensive dosing algorithm, is expected to improve dose optimisation and lower the risk of adverse drug reactions. As a complementary tool, a simple genotype-dosing table, such as in the US Food and Drug Administration (FDA) Coumadin drug label, may be utilised for general risk assessment of likely over- or under-anticoagulation on a st...

Genotype-guided dosing of warfarin.

Vitamin K antagonists (VKAs) have been used to treat thromboembolic disease for over 60 years, and they continue to be the most commonly prescribed anticoagulants worldwide. However, VKAs such as warfarin have a narrow therapeutic index, and the mean daily dose of warfarin varies widely from patient to patient. Underdosing can leave patients undertreated for their thromboembolic diseases; overd...

Revisiting Warfarin Dosing Using Machine Learning Techniques

Determining the appropriate dosage of warfarin is an important yet challenging task. Several prediction models have been proposed to estimate a therapeutic dose for patients. The models are either clinical models which contain clinical and demographic variables or pharmacogenetic models which additionally contain the genetic variables. In this paper, a new methodology for warfarin dosing is pro...

DNA-guided Warfarin Dosing Algorithm Protocol

Practical tips for warfarin dosing and monitoring.

Patients on warfarin and their physicians must constantly balance the risks of bleeding and clotting. We offer practical tips for safe and effective warfarin therapy, based on the practices of the Anticoagulation Clinic of The Cleveland Clinic.